PEAK 假激酶支架家族由 PEAK1（最初称为 SgK269）、PEAK2（SgK223，大鼠 Pragmin 的人类直系同源物）和 PEAK3 (C19orf35) 组成，已成为细胞信号传导的重要调节剂和整合剂，并且还在多种癌症中发挥致癌作用。人类癌症。这些蛋白质经历同型和异型关联，从而使信号输出多样化。最近，PEAK3 的结构和功能表征及其蛋白质-蛋白质相互作用揭示了 PEAK 信号传导动力学和 PEAK 家族成员的相互依赖性、PEAK 二聚化如何调节下游效应子的结合，以及 14-3-3 结合如何发挥作用来调节PEAK3信号输出。这些重要进展构成了本次审查的基础。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

The PEAK family of pseudokinase scaffolds, comprising PEAK1 (originally termed SgK269), PEAK2 (SgK223, the human orthologue of rat Pragmin) and PEAK3 (C19orf35), have emerged as important regulators and integrators of cellular signaling and also play oncogenic roles in a variety of human cancers. These proteins undergo both homo- and heterotypic association that act to diversify signal output. Recently, structural and functional characterization of PEAK3 and its protein-protein interactions have shed light on PEAK signaling dynamics and the interdependency of PEAK family members, how PEAK dimerization regulates the binding of downstream effectors, and how 14-3-3 binding acts to regulate PEAK3 signal output. These important advances form the basis of this review.Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.