背景/目标：磁性 Fe3O4 纳米颗粒 (MNP) 日益变得越来越重要。我们通过溶剂热法，在叠氮化物和炔烃官能化的聚乙二醇（PEG400）聚合物以及PEG6000和多元醇β-环糊精（βCD）的辅助下，通过简单的一步反应制备了MNP，这在以下方面发挥了至关重要的作用：静电稳定剂，在磁芯周围提供聚合物/多元醇涂层。方法：使用透射电子和原子力显微镜（TEM、AFM）、核磁共振（NMR）、X射线衍射仪（XRD）、傅里叶变换红外光谱仪分析纳米球的组成、形貌和磁性。 FT-IR）、基质辅助激光解吸/电离（MALDI）和振动样品磁力测定（VSM）。结果：所获得的纳米颗粒（@Fe3O4-PEGs 和 @Fe3O4-βCD）的直径在 90 至 250 nm 之间，具体取决于所用的聚合物和 Fe3O4·6H2O 前体浓度，通常在 200 °C 和反应 24 小时时为 0.13 M 。 MNPs在室温下表现出超顺磁性，具有高饱和质量磁化强度，达到59.9 emu/g（@Fe3O4-PEG6000），并且没有铁磁性。同样，他们在施加交变磁场 (AMF) 后表现出温度升高，@Fe3O4-PEG6000 的比吸收率 (SAR) 值高达 51.87 ± 2.23 W/g。此外，所形成的系统容易受到点击化学的影响，正如大麻二酚-炔丙基衍生物（CBD-Pro）所证明的那样，该衍生物是合成的并共价连接到@Fe3O4-PEG400-N3的叠氮官能化表面。制备的 MNP 在水、PBS 和柠檬酸盐缓冲液中高度分散，悬浮状态可保持超过 2 周，并且在 T84 人结肠癌细胞系中无毒。结论：表明它们是生物医学应用的理想候选者。

Background/Objectives: Magnetic Fe3O4 nanoparticles (MNPs) are becoming more important every day. We prepared MNPs in a simple one-step reaction by following the solvothermal method, assisted by azide and alkyne functionalized polyethylene glycol (PEG400) polymers, as well as by PEG6000 and the polyol β-cyclodextrin (βCD), which played a crucial role as electrostatic stabilizers, providing polymeric/polyol coatings around the magnetic cores. Methods: The composition, morphology, and magnetic properties of the nanospheres were analyzed using Transmission Electron and Atomic Force Microscopies (TEM, AFM), Nuclear Magnetic Resonance (NMR), X-ray Diffraction Diffractometry (XRD), Fourier-Transform Infrared Spectroscopy (FT-IR), Matrix-Assisted Laser Desorption/Ionization (MALDI) and Vibrating Sample Magnetometry (VSM). Results: The obtained nanoparticles (@Fe3O4-PEGs and @Fe3O4-βCD) showed diameters between 90 and 250 nm, depending on the polymer used and the Fe3O4·6H2O precursor concentration, typically, 0.13 M at 200 °C and 24 h of reaction. MNPs exhibited superparamagnetism with high saturation mass magnetization at room temperature, reaching values of 59.9 emu/g (@Fe3O4-PEG6000), and no ferromagnetism. Likewise, they showed temperature elevation after applying an alternating magnetic field (AMF), obtaining Specific Absorption Rate (SAR) values of up to 51.87 ± 2.23 W/g for @Fe3O4-PEG6000. Additionally, the formed systems are susceptible to click chemistry, as was demonstrated in the case of the cannabidiol-propargyl derivative (CBD-Pro), which was synthesized and covalently attached to the azide functionalized surface of @Fe3O4-PEG400-N3. Prepared MNPs are highly dispersible in water, PBS, and citrate buffer, remaining in suspension for over 2 weeks, and non-toxic in the T84 human colon cancer cell line, Conclusions: indicating that they are ideal candidates for biomedical applications.