亲脂性是化合物的一个重要参数，它决定了溶解度和药代动力学特性，从而决定了药物向分子靶点的转运。二吡啶并噻嗪二聚体是二氮杂吩噻嗪衍生物，在体外表现出多种抗癌潜力，这与其对组蛋白脱乙酰酶的亲和力有关。在这项研究中，通过丙酮-TRIS缓冲液（pH = 7.4）中的反相薄层色谱（RP-TLC）从理论上和实验上研究了16种异构体二吡啶并噻嗪二聚体的亲脂性。相对亲脂性参数 RM0 和比疏水表面积 b 显着相关，显示二聚体的同类类别。利用校准曲线将参数 RM0 转换为参数 logPTLC。通过计算机确定分子描述符、ADMET 参数和可能的分子靶标，以分析显示抗癌活性的测试化合物的药代动力学特征。所分析的化合物在利平斯基五法则、高斯法则和韦伯法则的背景下进行了测试，证实了它们的生物利用度。

Lipophilicity is an essential parameter of a compound that determines the solubility and pharmacokinetic properties that determine the transport of the drug to the molecular target. Dimers of dipyridothiazines are diazaphenothiazine derivatives exhibiting diverse anticancer potential in vitro, which is related to their affinity for histone deacetylase. In this study, the lipophilicity of 16 isomeric dipyridothiazine dimers was investigated theoretically and experimentally by reversed-phase thin-layer chromatography (RP-TLC) in an acetone-TRIS buffer (pH = 7.4). The relative lipophilicity parameter RM0 and specific hydrophobic surface area b were significantly intercorrelated, showing congeneric classes of dimers. The parameter RM0 was transformed into parameter logPTLC by use of the calibration curve. Molecular descriptors, ADMET parameters and probable molecular targets were determined in silico for analysis of the pharmacokinetic profile of the tested compounds showing anticancer activity. The analyzed compounds were tested in the context of Lipinski's rule of five, Ghose's rule and Veber's rule, confirming their bioavailability.