免疫检查点抑制剂与新型疗法相结合的前景：对抗乳腺癌的秘密联盟。
The landscape of combining immune checkpoint inhibitors with novel Therapies: Secret alliances against breast cancer.
发表日期：2024 Nov
作者：
Federico Rebaudi, Fabiana De Franco, Rayan Goda, Valentina Obino, Giorgio Vita, Camilla Baronti, Eleonora Iannone, Francesca Pitto, Barbara Massa, Daniela Fenoglio, Camilla Jandus, Francesca Poggio, Piero Fregatti, Ombretta Melaiu, Matteo Bozzo, Simona Candiani, Federica Papaccio, Marco Greppi, Silvia Pesce, Emanuela Marcenaro
来源：
CANCER TREATMENT REVIEWS
摘要：
本综述重点关注乳腺癌 (BC) 治疗背景下的免疫检查点抑制剂 (ICIs)。这些创新疗法通过靶向肿瘤和免疫细胞上表达的蛋白质，旨在克服肿瘤诱导的免疫抑制并重新激活免疫系统。这种方法的潜力是众多临床研究的主题。在这里，我们探讨了与 ICI 相关的关键研究和新兴疗法，详细分析了它们在 BC 治疗中的具体和联合使用。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。
This review focuses on the immune checkpoint inhibitors (ICIs) in the context of breast cancer (BC) management. These innovative treatments, by targeting proteins expressed on both tumor and immune cells, aim to overcome tumor-induced immune suppression and reactivate the immune system. The potential of this approach is the subject of numerous clinical studies. Here, we explore the key studies and emerging therapies related to ICIs providing a detailed analysis of their specific and combined use in BC treatment.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.