骨盆肿瘤切除和重建是一项复杂的外科手术，尽管在稳定骨盆结构方面取得了进展，但对软组织重建提出了挑战。本研究旨在探讨使用聚醚醚酮 (PEEK) 材料修复和重建骨盆植入物周围软组织的潜力。具体来说，该研究重点探索3D打印多孔PEEK材料在促进细胞生长和粘附方面的有效性。通过细胞实验和动物实验评估不同孔径（200、400、600 µm）和不同规格（通孔（T）/非通孔（C））的 PEEK 材料之间的相互作用。通过细胞生长和粘附观察评估PEEK材料的软组织向内生长潜力。研究结果表明，PEEK 材料，尤其是 T400 变体，与骨骼和纤维组织的相互作用相比，与肌肉组织的相互作用更强。 T400材料中存在的中等大小的孔有利于增强细胞粘附和渗透，从而促进细胞生长和分化。具有通孔结构的 PEEK 材料在涉及软组织和肌肉组织修复和重建的应用中显示出前景。该研究为生物医学材料（特别是 PEEK）的开发和应用提供了宝贵的见解，有助于盆腔肿瘤切除和重建技术的进步。© 2024 Wiley‐VCH GmbH。

Bone pelvis tumor resection and reconstruction is a complex surgical procedure that poses challenges in soft tissue reconstruction despite advancements in stabilizing pelvic structure. This study aims to investigate the potential of using Polyetheretherketone (PEEK) material in repairing and reconstructing soft tissues surrounding pelvic implants. Specifically, the study focuses on exploring the effectiveness of 3D printed porous PEEK material in promoting cell growth and adhesion. The interaction between PEEK materials with different pore sizes (200, 400, 600 µm) and different specifications (through-hole (T)/non-through-hole (C)) is evaluated by cell experiments and animal experiments. The soft tissue ingrowth potential of PEEK materials is evaluated by cell growth and adhesion observation. The findings indicate that PEEK material, particularly the T400 variant, exhibits stronger interaction with muscle tissue compared to its interaction with bone and fibrous tissue. The moderately sized pores present in the T400 material facilitate enhanced cell adhesion and penetration, thereby promoting cell growth and differentiation. PEEK materials with through-hole structures show promise for applications involving the repair and reconstruction of soft tissues and muscle tissue. The study provides valuable insights into the development and application of biomedical materials, specifically PEEK, contributing to the advancement of pelvic tumor resection and reconstruction techniques.© 2024 Wiley‐VCH GmbH.