损伤相关分子模式 (DAMP) 是细胞响应损伤或应激而释放的内源性分子，被宿主模式识别受体识别，评估细胞损伤的免疫学意义。 DAMP 和先天免疫受体之间的相互作用会引发无菌炎症，其具有双重目的：促进组织修复并导致病理状况，包括与年龄相关的疾病。 DAMP 介导的慢性炎症会加速免疫衰老，影响肿瘤进展和抗肿瘤免疫，这凸显了 DAMP 在衰老和癌症之间关系中的关键作用。本综述探讨了免疫衰老的特征及其对年龄相关癌症的影响，研究了各种类型的 DAMP、它们在细胞死亡过程中的释放机制以及它们启动的免疫激活途径。此外，我们还研究了靶向 DAMP 在与年龄相关的疾病中的治疗潜力。对 DAMP 诱导的信号转导的详细了解可以为免疫调节提供重要见解，并支持创新治疗策略的开发。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Damage-associated molecular patterns (DAMPs) are endogenous molecules released by cells in response to injury or stress, recognized by host pattern recognition receptors that assess the immunological significance of cellular damage. The interaction between DAMPs and innate immune receptors triggers sterile inflammation, which serves a dual purpose: promoting tissue repair and contributing to pathological conditions, including age-related diseases. Chronic inflammation mediated by DAMPs accelerates immunosenescence and influences both tumor progression and anti-tumor immunity, underscoring the critical role of DAMPs in the nexus between aging and cancer. This review explores the characteristics of immunosenescence and its impact on age-related cancers, investigates the various types of DAMPs, their release mechanisms during cell death, and the immune activation pathways they initiate. Additionally, we examine the therapeutic potential of targeting DAMPs in age-related diseases. A detailed understanding of DAMP-induced signal transduction could provide critical insights into immune regulation and support the development of innovative therapeutic strategies.Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.