此前，嗜酸性粒细胞主要被认为是参与过敏性疾病和寄生虫感染的效应毒性细胞。然而，新的研究表明，嗜酸性粒细胞具有多样性，并且对于免疫调节和组织稳态至关重要。它们的功能可塑性已在患有炎症性疾病、癌症、感染和其他疾病的患者中观察到。虽然在稳态期间肝脏内很少观察到嗜酸性粒细胞，但在各种肝脏疾病中，嗜酸性粒细胞会被募集到肝脏，包括肝寄生虫病、急性肝损伤、自身免疫性肝病和肝细胞癌。此外，嗜酸性粒细胞已被证明具有促进肝再生的能力。本文探讨了嗜酸性粒细胞在肝脏疾病中的多方面作用，旨在提供见解，从而为这些疾病提供更有效的临床治疗。版权所有 © 2024 作者。由爱思唯尔公司出版。保留所有权利。

Previously, eosinophils were primarily regarded as effector toxic cells involved in allergic diseases and parasitic infections. Nevertheless, new research has shown that eosinophils are diverse and essential for immune regulation and tissue homeostasis. Their functional plasticity has been observed in patients with inflammatory diseases, cancer, infections, and other disorders. While eosinophils are infrequently observed within the liver during periods of homeostasis, they are recruited to the liver in various liver diseases, including liver parasitosis, acute liver injury, autoimmune liver disease, and hepatocellular carcinoma. Furthermore, eosinophils have demonstrated the capacity to promote liver regeneration. This article explores the multifaceted roles of eosinophils in liver diseases, aiming to provide insights that could lead to more effective clinical therapies for these conditions.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.