胆汁酸（BA）具有有效调节自身代谢和运输以及脂质和葡萄糖稳态的关键方面的信号传导功能。 BA 塑造肠道微生物菌群，反过来又被微生物群代谢。 BA 转运、代谢和生理信号功能的破坏会导致多种肝脏疾病的发病机制和进展，包括胆汁淤积性疾病和代谢功能障碍相关的脂肪性肝病 (MASLD) 以及肝细胞癌和胆管细胞癌。此外，BA信号传导受损还可能影响肠道和肾脏，从而导致肠道完整性受损，进而导致门脉高压、胆汁性肾病的进展和并发症以及结直肠癌等肝外恶性肿瘤的发展。这篇综述将总结对 BA 信号传导、代谢和运输的理解的最新进展，重点关注转录调控以及以 BA 为中心的胆汁淤积性和代谢性肝病的新型治疗策略。版权所有 © 2024 作者。由 Elsevier B.V. 出版。保留所有权利。

Bile acids (BAs) have signaling functions efficiently regulating their own metabolism and transport as well as key aspects of lipid and glucose homeostasis. BAs shape the gut microbial flora and conversely are metabolized by microbiota. Disruption of BA transport, metabolism and physiological signaling function contribute to the pathogenesis and progression of a wide range of liver diseases including cholestatic disorders and metabolic dysfunction-associated steatotic liver disease (MASLD) as well as hepatocellular and cholangiocellular carcinoma. Additionally, impaired BA signaling may also affect the intestine and kidney, thereby contributing to failure of gut integrity driving the progression and complications of portal hypertension, cholemic nephropathy and the development of extrahepatic malignancies such as colorectal cancer. This review will summarize recent advances in the understanding of BA signaling, metabolism and transport focusing on transcriptional regulation and novel BA-focused therapeutic strategies for cholestatic and metabolic liver diseases.Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.