诱导血管生成这一经典的癌症标志源于人们长期以来的观念，即只有形成新血管，肿瘤才能生长。基于这一前提，通过治疗性抑制血管生成以期控制肿瘤生长的尝试并未如预期有效。这部分是因为原发性和转移性肿瘤可以在没有血管生成的情况下生长。非血管生成性癌症及其利用正常血管的机制（称为“血管选择”）的发现开辟了癌症生物学的新领域。因此，癌症标志“诱导血管生成”已被修改为“诱导或进入脉管系统”。版权所有 © 2024。由 Elsevier Inc. 出版。

The classic cancer hallmark, inducing angiogenesis, was born out of the long-held notion that tumours could grow only if new vessels were formed. The attempts, based on this premise, to therapeutically restrain angiogenesis in hopes of controlling tumour growth have been less effective than expected. This is partly because primary and metastatic tumours can grow without angiogenesis. The discovery of nonangiogenic cancers and the mechanisms they use to exploit normal vessels, called 'vessel co-option,' has opened a new field in cancer biology. Consequently, the cancer hallmark, 'inducing angiogenesis,' has been modified to 'inducing or accessing vasculature.'Copyright © 2024. Published by Elsevier Inc.