解决问题：武装自然杀伤细胞对抗卵巢癌。
Ironing Out the Kinks: Arming Natural Killer Cells against Ovarian Cancer.
发表日期：2024 Oct 04
作者：
Hannah Noelle Bell, Weiping Zou
来源：
Cancer Discovery
摘要：
改善肿瘤免疫微环境是改善癌症患者治疗效果的关键策略。 Sandoval 及其同事证明，铁螯合可以增强 I 型干扰素的产生，促进 NK 细胞肿瘤的运输和激活，并与化疗药物顺铂协同作用，以减少小鼠模型中转移性卵巢癌的进展。请参阅 Sandoval 等人的相关文章，第 17 页。 1901.©2024 美国癌症研究协会。
Ameliorating the tumor immune microenvironment is a key strategy to improve the therapeutic outcomes of patients with cancer. Sandoval and colleagues demonstrate that iron chelation enhances type I IFN production, promotes NK cell tumor trafficking and activation, and synergizes with chemotherapy drug cisplatin to reduce metastatic ovarian cancer progression in murine models. See related article by Sandoval et al., p. 1901.©2024 American Association for Cancer Research.