化疗引起的周围神经病变（CIPN）是奥沙利铂引起的一种常见的剂量限制性化学毒性。本研究使用来自重点降低结肠癌抗阻运动剂量限制毒性试验（ClinicalTrials.gov 标识符 NCT03291951）的数据，调查了结肠癌幸存者的饮食质量与中度和/或重度 CIPN 发生之间的关系。 饮食质量使用 127 项食物频率调查问卷收集数据，并使用 2010 年替代健康饮食指数 (AHEI-2010) 进行评分。 CIPN 在每个化疗周期使用不良事件通用术语标准的患者报告结果版本进行评估。使用 Cox 比例风险模型估计膳食质量与首次中度至重度（中重度）或重度 CIPN 事件的时间之间的关联。本分析仅包括接受奥沙利铂治疗的参与者 (n = 132)。74 名参与者 (56.1%) 报告中度至重度 CIPN。较高的膳食质量与中重度 CIPN（风险比 [HR]，0.96；95% 置信区间 [CI]，0.93-0.99）和重度 CIPN（HR，0.91；95% CI，0.85-）风险显着降低相关。 0.98）。食用红肉和加工肉类（HR，1.78；95% CI，1.07-2.83）和含糖饮料（HR，1.33；95% CI，1.10-1.59）与中重度 CIPN 风险增加相关。食用含糖饮料也与严重 CIPN 风险增加相关（HR，1.57；95% CI，1.14-2.18），而蔬菜食用与严重 CIPN 风险降低相关（HR，0.29；95% CI） ，0.09-0.73)。在接受奥沙利铂化疗的结肠癌患者中，较高的基线饮食质量与中重度 CIPN 风险降低相关。© 2024 美国癌症协会。

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting chemotoxicity caused by oxaliplatin. This study investigated the relationship between dietary quality and the development of moderate and/or severe CIPN in colon cancer survivors using data from the Focus on Reducing Dose-Limiting Toxicities in Colon Cancer with Resistance Exercise trial (ClinicalTrials.gov identifier NCT03291951).Diet quality was collected using a 127-item food-frequency questionnaire and was scored using the Alternative Healthy Eating Index-2010 (AHEI-2010). CIPN was assessed with the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events at each chemotherapy cycle. The association of dietary quality with time to the first moderate-to-severe (moderate-severe) or severe event of CIPN was estimated using Cox proportional hazards models. Only participants who received oxaliplatin were included in this analysis (n = 132).Seventy-four participants (56.1%) reported moderate-severe CIPN. Higher dietary quality was associated with a significantly decreased risk of moderate-severe CIPN (hazard ratio [HR], 0.96; 95% confidence interval [CI], 0.93-0.99) and severe CIPN (HR, 0.91; 95% CI, 0.85-0.98). Consumption of red and processed meat (HR, 1.78; 95% CI, 1.07-2.83) and sugar-sweetened beverages (HR, 1.33; 95% CI, 1.10-1.59) was associated with an increased risk of moderate-severe CIPN. Consumption of sugar-sweetened beverages also was associated with an increased risk of severe CIPN (HR, 1.57; 95% CI, 1.14-2.18), whereas vegetable consumption was associated with a reduced risk of severe CIPN (HR, 0.29; 95% CI, 0.09-0.73).Among patients with colon cancer who received oxaliplatin-based chemotherapy, higher baseline dietary quality was associated with a reduced risk of moderate-severe CIPN.© 2024 American Cancer Society.