随着对肿瘤微环境的深入了解，新兴研究揭示了癌症相关微生物群在支持癌症发生、进展和传播中的关键作用。特别是，隐藏在肿瘤组织内各种细胞中的某些侵入性细菌可以通过癌症生物学多个分支中涉及的复杂机制帮助肿瘤生长和侵袭。因此，肿瘤细胞内微生物有望成为下一代肿瘤治疗靶点。本综述旨在深入研究这些内化细菌驱动的促癌机制，并探索多样化的抗菌治疗策略，以抵消这些入侵者造成的有害影响，从而提高抗肿瘤治疗的疗效。版权所有 © 2024 Elsevier B.V. 保留所有权利。

Emerging studies have disclosed the pivotal role of cancer-associated microbiota in supporting cancer development, progression and dissemination, with the in-depth comprehending of tumor microenvironment. In particular, certain invasive bacteria that hide in various cells within the tumor tissues can render assistance to tumor growth and invasion through intricate mechanisms implicated in multiple branches of cancer biology. Thus, tumor-resident intracellular microbes are anticipated as next-generation targets for oncotherapy. This review is intended to delve into these internalized bacteria-driven cancer-promoting mechanisms and explore diversified antimicrobial therapeutic strategies to counteract the detrimental impact caused by these intruders, thereby improving therapeutic benefit of antineoplastic therapy.Copyright © 2024 Elsevier B.V. All rights reserved.