研究动态
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肠道微生物组和膀胱癌:亚硝胺代谢的新联系。

Gut microbiome and bladder cancer: A new link through nitrosamine metabolism.

发表日期:2024 Oct 09
作者: Sridhar Mani
来源: Cell Host & Microbe

摘要:

《自然》杂志最近发表的一篇论文1揭示,肠道微生物在肠道中将 N-丁基-N-(4-羟丁基)-亚硝胺 (BBN) 代谢为膀胱致癌物 N-正丁基-N-(3-羧丙基)-亚硝胺 (BCPN),从而建立了肠道微生物活动与膀胱癌发展之间存在直接联系。版权所有 © 2024 Elsevier Inc. 保留所有权利。
A recent Nature paper1 reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer.Copyright © 2024 Elsevier Inc. All rights reserved.