目前尚不确定低剂量计算机断层扫描 (LDCT) 检测到的纯磨玻璃结节 (pGGN) 应随访多长时间。需要进一步进行更长随访期的研究来确定 pGGN 的最佳随访时间。pGGN 中增大的结节在 10 年内保持稳定的百分比是多少？这是一项源自检测到 pGGN 受试者的回顾性队列研究1997 年至 2006 年间的 LDCT 扫描，其自然病程于 2013 年报告。我们重新分析了 2022 年 7 月之前的所有随访数据。研究对象遵循我们的机构指南，直到他们不再是最终治疗的候选者。 pGGN 的生长定义为整个结节直径增加 2 毫米或更多，或结节内出现新的实性部分。总共对 89 名具有 135 个 pGGN 的患者进行了中位随访 193 个月。在 135 个 pGGN 中，23 个 (17.0%) 尺寸增大，首次检测到尺寸变化的中位时间为 71 个月。在 23 个生长的 pGGN 中，有 122 个是在第一次 LDCT 中检测到的，13 个是在后续 CT 扫描中新检测到的。 5 年内观察到大小增加的有 8 个结节 (34.8%)，5 至 10 年内观察到的大小增加有 12 个结节 (52.2%)，10 年后观察到的大小有 3 个结节 (13.0%)。 15个结节经手术组织学证实为腺癌。在稳定10年的76个pGGN中，有3个（3.9%）尺寸增加。在保持稳定10年的pGGN中，3.9%最终增长，表明一些pGGN即使在长期稳定后仍能生长。我们建议 pGGN 可能需要跟踪 10 年以上才能确认增长。版权所有 © 2024。由 Elsevier Inc. 出版。

It remains uncertain how long pure ground-glass nodules (pGGNs) detected on low dose computed tomography (LDCT) should be followed. Further studies with longer follow-up periods are needed to determine the optimal follow-up duration for pGGNs.What is the percentage of enlarging nodules among pGGNs that have remained stable for 10 years?This was a retrospective cohort study originating from subjects with pGGNs detected on LDCT scans between 1997 and 2006, whose natural courses were reported in 2013. We re-analyzed all the follow-up data until July 2022. The study subjects were followed by our institutional guidelines until they were no longer a candidate for definitive treatment. The growth of the pGGNs was defined as an increase in the diameter of the entire nodule by 2 mm or more or the appearance of new solid portions within the nodules.A total of 89 patients with 135 pGGNs were followed for a median of 193 months. Of 135 pGGNs, 23 (17.0%) increased in size, and the median time to the first detection of a size change was 71 months. Of the 23 growing pGGNs, 122 were detected on the first LDCT, and 13 were newly detected on the follow-up CT scan. An increase in size was observed within 5 years in 8 nodules (34.8%), between 5 and 10 years in 12 nodules (52.2%) and after 10 years in 3 nodules (13.0%). Fifteen nodules were histologically confirmed as adenocarcinoma by surgery. Among the 76 pGGNs stable for 10 years, 3 (3.9%) increased in size.Among pGGNs that remained stable for 10 years, 3.9% eventually grew, indicating that some pGGNs can grow even after a long period of stability. We suggest that pGGNs may need to be followed for more than 10 years to confirm growth.Copyright © 2024. Published by Elsevier Inc.