柑橘类水果被广泛种植，可以生食或精制食用。柑橘类水果皮富含多酚物质。这使它们成为有用的资源。柑橘皮中发现的多甲氧基黄酮 (PMF) 属于黄酮类化合物的一个特定亚类，其中大部分或所有羟基都被甲基化。 PMF 已被证明具有化学预防作用、抗癌、抗炎、抗动脉粥样硬化特性以及神经保护作用。 Sudachitin 是一种 PMF，主要存在于柑橘酸橘中。日本德岛县是这种著名水果的故乡。近年来，由于sudachitin在传统饮食中的存在及其与各种积极的健康结果的关联，研究人员对探索sudachitin的潜在健康益处越来越感兴趣。过去十年进行的研究表明，sudachitin 在多种健康状况中具有良好的效果，包括癌症、皮肤病、炎症、糖尿病、肥胖和神经退行性疾病。尽管存在这些有希望的结果，但仍然需要进行彻底的临床前和临床研究，以证实 Sudachitin 在治疗慢性疾病方面的有效性。本综述旨在总结动物和细胞研究，探索 Sudachitin 的药理学特性及其治疗作用的潜在分子途径。通过这一点，我们的目标是阐明 sudachitin 在各种疾病中的临床潜力，为未来的研究和基于 sudachitin 的疗法的开发铺平道路。© 2024 Wiley periodicals LLC。

Citrus fruits are extensively cultivated and eaten both raw and in refined forms. Citrus fruit peels are highly concentrated in polyphenolic substances. This makes them useful resources. Polymethoxyflavones (PMFs), found in citrus peels, belong to a specific subclass of flavonoids where most or all hydroxyl groups are methylated. PMFs have been documented to possess chemopreventive actions, anticancer, anti-inflammatory, and anti-atherosclerosis properties, as well as neuroprotective effects. Sudachitin, a PMF, is primarily found in Citrus sudachi. Japan's Tokushima prefecture is home to this famous fruit. In recent years, there has been a growing interest among researchers in exploring the potential health benefits of sudachitin, spurred by its presence in traditional diets and its association with various positive health outcomes. Studies conducted over the past decade have revealed promising effects of sudachitin in multiple health conditions, including cancer, skin disorders, inflammatory conditions, diabetes, obesity, and neurodegenerative disorders. Although these promising results exist, there is still a need for thorough preclinical and clinical research to confirm sudachitin's effectiveness in treating chronic conditions. This review seeks to summarize animal and cell studies exploring sudachitin's pharmacological properties and the potential molecular pathways underlying its therapeutic effects. Through this, we aim to clarify the clinical potential of sudachitin across various disorders, paving the way for future research and the development of sudachitin-based therapies.© 2024 Wiley Periodicals LLC.