耐药性是癌症患者治疗失败的主要原因。因此，需要创新的治疗策略来克服这一关键挑战并改善患者的治疗结果。在这篇综述中，我们研究了基于肽的疗法对抗癌症耐药性的潜力。我们重点介绍使用肽可以探索的独特策略和机制，包括它们选择性靶向肿瘤、促进药物输送到癌细胞以及抑制驱动癌症进展和抵抗的关键细胞内蛋白质的能力。肽提供了一种有前途的方法来克服癌症对化疗、靶向治疗和生物制剂的内在和适应性耐药性。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Drug resistance is the leading cause of treatment failure in patients with cancer. Thus, innovative therapeutic strategies are required to overcome this critical challenge and improve patient outcomes. In this review, we examine the potential of peptide-based therapies to combat drug resistance in cancer. We highlight the unique strategies and mechanisms that can be explored by using peptides, including their ability to selectively target tumours, facilitate drug delivery into cancer cells, and inhibit key intracellular proteins that drive cancer progression and resistance. Peptides offer a promising approach to overcoming both intrinsic and adaptative cancer resistance against chemotherapy, targeted therapies, and biologics.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.