硼中子捕获疗法（BNCT）是一种创新的放射疗法，在癌症治疗中具有巨大潜力。本系统综述旨在全面评估 BNCT 在各种癌症类型中的有效性、安全性和适用性。按照 PRISMA（系统评价和荟萃分析的首选报告项目）指南，我们在 PubMed、Scopus、Cochrane CENTRAL、 ClinicalTrials.gov 和 ICTRP 从成立到 2023 年 5 月 27 日。根据预定义的标准选择符合条件的研究，并使用 IBM SPSS（社会科学统计包）进行统计分析，以评估组织学因素、治疗结果和治疗结果之间的相关性。初步检索确定了 925 项研究（498 项来自 Scopus、333 项来自 PubMed、16 项来自 ClinicalTrials.gov、41 项来自 ICTRP、30 项来自 Cochrane CENTRAL）。在删除重复项并应用选择标准后，对 121 篇全文文章进行了评估，其中 39 项研究符合纳入标准。同行评审过程中纳入了 2024 年发表的另一项研究，使研究总数达到 40 项。分析显示，BNCT 在治疗各种癌症方面表现出良好的疗效，且安全性可控。然而，研究中注意到了结果的变异性和不良反应。BNCT 作为多种癌症类型的治疗方式显示出巨大的前景，提供了潜在的益处和可接受的安全性。尽管如此，进一步的研究对于完善其临床应用并确保一致的安全性和有效性至关重要。

Boron Neutron Capture Therapy (BNCT) is an innovative radiation therapy with significant potential in cancer treatment. This systematic review aimed to comprehensively evaluate the efficacy, safety, and applicability of BNCT across various cancer types.Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we conducted a systematic search in PubMed, Scopus, Cochrane CENTRAL, ClinicalTrials.gov, and ICTRP from inception until May 27, 2023. Eligible studies were selected based on predefined criteria, and statistical analyses were performed using IBM SPSS (Statistical Package for the Social Sciences) to assess correlations between histological factors, treatment outcomes, and adverse effects.The initial search identified 925 studies (498 from Scopus, 333 from PubMed, 16 from ClinicalTrials.gov, 41 from ICTRP, and 30 from Cochrane CENTRAL). After removing duplicates and applying selection criteria, 121 full-text articles were assessed, with 39 studies meeting the inclusion criteria. An additional study published in 2024 was included during the peer review process, bringing the total to 40 studies. The analysis revealed that BNCT demonstrates promising efficacy across various cancers, with a manageable safety profile. However, outcome variability and adverse effects were noted among the studies.BNCT shows substantial promise as a treatment modality for multiple cancer types, offering potential benefits with acceptable safety profiles. Nonetheless, further research is essential to refine its clinical application and ensure consistent safety and efficacy.