印度的宫颈癌负担占全球的五分之一。与人乳头瘤病毒（HPV）自我采样不同，其他筛查方法可能会引起不适和尴尬。本研究旨在调查居住在不同环境和不同文化水平的印度妇女的态度、可接受性、障碍、预测因素、有效指导方式以及 HPV 自我采样的有效性。这是一项以社区为基础的干预研究，对象是居住在城市贫民窟（500 名）、城市非贫民窟（500 名）和农村（600 名）环境中的 30-55 岁印度女性，这些女性拥有不同的盥洗设施和隐私，旨在收集自我样本。每组又分为两组；一名妇女通过小册子接受教育，另一名妇女通过健康教育计划 (HEP) 接受教育。研究涉及招募符合条件的人、获得知情同意并进行个人访谈以收集基线数据。向自采样器分发了有关使用、储存和归还的说明（一组为图画小册子，另一组为 HEP）。使用自我采样器的意愿、拒绝、经验等都被捕获。记录干预后的知识、态度、实践。 HPV 报告已分发。两项测试均呈阳性的女性将接受进一步的治疗。城市非贫民窟、城市贫民窟和农村妇女的自我采样接受率分别为99.2%、97%和98.8%，HPV阳性率分别为7%、7.8%和8.5%。卫生人员采集的样本与自行采集的样本之间的一致性在小册子中为 96.5%，在 HEP 组中为 93.2%。自我采样的主要障碍是对正确进行自测缺乏信心、担心测试会很痛苦以及对测试结果感到焦虑。 HPV 自我采样在印度女性中具有良好的可接受性，并且与卫生人员采集的样本具有良好的一致性。© 2024 作者。约翰·威利出版的《国际癌症杂志》

India records one fifth of global cervical cancer burden. Unlike human papillomavirus (HPV) self-sampling, other screening methods may cause discomfort and embarrassment. This study aimed to investigate attitudes, acceptability, barriers, predictors, effective modality of instructions, and validity of HPV self-sampling among Indian women residing in varied settings and different literacy levels. This is community-based interventional study among Indian women 30-55 years, residing in urban slums (500), urban non-slums (500), and rural (600) settings with varied washroom facilities and privacy, to collect self-samples. Each group was subdivided into two arms; in one women received education with pamphlets and other with health education program (HEP). Study involved enlisting eligibles, obtaining informed consents and conducting personal interviews to collect baseline data. Self-samplers were distributed with instructions (pictorial pamphlets in one group and HEP in other) regarding usage, storage and return. Willingness to use self-samplers, refusals, experiences, and so forth were captured. Post-intervention knowledge, attitudes, practices was recorded. HPV reports were distributed. Women with positive result on either test were offered further management. Acceptance rate of self-sampling was 99.2%, 97%, and 98.8% and HPV positivity was 7%, 7.8%, and 8.5%, respectively among urban non-slum, urban slum and rural women. Agreement rate between health personnel collected and self-collected samples was 96.5% in pamphlet and 93.2% in HEP arm. Major barriers of self-sampling were lack of confidence about performing self-test correctly, fear that test would be painful and anxiety about test results. HPV self-sampling has good acceptability among Indian women and good agreement with health personnel collected samples.© 2024 The Author(s). International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.