RET 介导的信号转导机制。
Mechanisms of RET mediated signal transduction.
发表日期：2024 Oct 01
作者：
Francesca Carlomagno, Marialuisa Moccia, Giorgia Federico, Massimo Santoro
来源：
ENDOCRINE-RELATED CANCER
摘要：
RET 受体酪氨酸激酶在生理上受到胶质细胞源性神经营养因子 (GDNF) 家族 (GFL) 的生长因子和生长分化因子 15 (GDF15) 细胞因子的刺激。 RET 在正常发育以及各种人类肿瘤和发育障碍中发挥着关键作用。本综述重点关注 RET 信号传导机制及其在人类疾病中的改变。
The RET receptor tyrosine kinase is physiologically stimulated by growth factors belonging to the glial cell line-derived neurotrophic factor (GDNF) family (GFLs) and by the growth differentiation factor-15 (GDF15) cytokine. RET plays a critical role in normal development as well as in various human tumors and developmental disorders. This review focuses on mechanisms of RET signaling and their alterations in human diseases.