将软组织肉瘤（STS）治疗集中在专家中心，并通过跨学科肿瘤委员会（ITB）实施综合治疗理念，取得了显着的治疗进展。然而，我们对 ITB 建议的实施及其对患者结果的影响的了解有限。在这项回顾性分析中，我们检查了 222 名患有原发性 STS 的成年患者 (pts)，这些患者在 2015 年至 2020 年间就诊于 Charité 综合癌症中心的 ITB。在局部疾病 (n = 188) 中，71 名患者被建议切除% (n = 134) 分。推荐治疗方式为化疗伴或不伴局部深部热疗，推荐放疗的比例分别为 37% (n = 69)、26% (n = 48) 和 52% (n = 97)。 29% (n = 54) 建立了复杂的多学科概念，包括 ≥ 3 种治疗方式。无论是患者还是治疗医生的选择，仅部分依从性与较高的进展风险 (HR 4.0 95%-CI 1.6-9.7 p < .01) 和死亡率 (HR 5.3 95%-CI 1.7-16.4 p) 相关。 < .01)。由于并发症或快速进展而无法遵循 ITB 建议的患者表现出高风险特征，死亡率和进展率增加（HR 18.1 95%-CI 8.5-38.2 p < .001；HR 21.5 95%-CI 8.5-54.7 p < .001)。据我们所知，这是德国综合癌症中心首次对 STS 治疗依从性进行分析。它提供了进一步的现实世界证据，表明完全遵守 ITB 建议以及遵守这些建议的能力对患者的预后具有预后价值，并强调了跨学科决策和治疗计划对 STS 患者的重要性。© 2024 作者。约翰·威利出版的《国际癌症杂志》

Centralising soft tissue sarcoma (STS) treatment in expert centres and implementing comprehensive therapy concepts through interdisciplinary tumour boards (ITB) has led to significant treatment progress. However, our knowledge on the implementation of the ITB recommendations and its impact on patient outcome is limited. In this retrospective analysis, we examined a cohort of 222 adult patients (pts) with primary STS who were presented to the ITB of the Charité Comprehensive Cancer Centre between 2015 and 2020. In localised disease (n = 188), resection was recommended in 71% (n = 134) of pts. The treatment modalities chemotherapy with or without regional deep hyperthermia, and radiotherapy were recommended in 37% (n = 69), 26% (n = 48) and 52% (n = 97), respectively. Complex multidisciplinary concepts were established in 29% (n = 54) including ≥3 treatment modalities. Only partial adherence, either by choice of patient or treating physician, was associated with a higher risk of both progression (HR 4.0 95%-CI 1.6-9.7 p < .01) and mortality (HR 5.3 95%-CI 1.7-16.4 p < .01). Pts inable to follow the ITB recommendations due to complications or rapid progression showed a high-risk profile with increased mortality and progression rates (HR 18.1 95%-CI 8.5-38.2 p < .001; HR 21.5 95%-CI 8.5-54.7 p < .001). To our knowledge, this represents the first German Comprehensive Cancer Centre analysis of therapy adherence in STS. It provides further real-world evidence that full adherence to ITB recommendations and the ability to adhere to them are of prognostic value for patient outcome and underlines the importance of interdisciplinary decision-making and treatment planning for STS patients.© 2024 The Author(s). International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.