近几十年来，癌症已成为人类努力克服的一个具有挑战性的障碍。与传统方法相比，光疗和免疫疗法是两种新兴疗法，但它们各有其优点和局限性。这些局限性包括容易转移和复发、反应率低和副作用大。为了解决这些问题，研究人员越来越关注利用纳米药物递送系统结合这两种疗法，因其优越的靶向效果和高载药率，取得了显着的效果。该联合疗法显示出增强的反应效率和有效性，从而导致制剂具有高度针对性、反应性和低复发率。本文综述了近五年来基于纳米药物递送系统的联合治疗中观察到的几种主要抗肿瘤作用机制。此外，还讨论了这种联合疗法的挑战和未来前景。© 2024。作者。

In recent decades, cancer has posed a challenging obstacle that humans strive to overcome. While phototherapy and immunotherapy are two emerging therapies compared to traditional methods, they each have their advantages and limitations. These limitations include easy metastasis and recurrence, low response rates, and strong side effects. To address these issues, researchers have increasingly focused on combining these two therapies by utilizing a nano-drug delivery system due to its superior targeting effect and high drug loading rate, yielding remarkable results. The combination therapy demonstrates enhanced response efficiency and effectiveness, leading to a preparation that is highly targeted, responsive, and with low recurrence rates. This paper reviews several main mechanisms of anti-tumor effects observed in combination therapy based on the nano-drug delivery system over the last five years. Furthermore, the challenges and future prospects of this combination therapy are also discussed.© 2024. The Author(s).