衰老和癌症中的 IL-1 信号传导：揭示了炎症反馈回路。
IL-1 signaling in aging and cancer: An inflammaging feedback loop unveiled.
发表日期：2024 Oct 08
作者：
Mingyong Liu, Bo Zhu, Qi-Jing Li
来源：
CANCER CELL
摘要：
Park 等人在一篇《科学》论文中。确定白细胞介素 (IL)-1α 是炎症正反馈的关键驱动因素，将衰老相关的 DNMT3A 下调与肺髓细胞中 IL-1α 产量增加联系起来。这会触发骨髓中的紧急骨髓生成，放大髓样介导的肿瘤内免疫抑制，从而促进老年小鼠的肿瘤进展。版权所有 © 2024 Elsevier Inc. 保留所有权利。
In a Science paper, Park et al. identified interleukin (IL)-1α as a key driver of positive feedback in inflammaging, linking aging-associated downregulation of DNMT3A to increased IL-1α production in lung myeloid cells. This triggers emergency myelopoiesis in the bone marrow, amplifying myeloid-mediated intratumoral immunosuppression for tumor progression in aged mice.Copyright © 2024 Elsevier Inc. All rights reserved.