本研究评估光声 (PA)、声触弹性成像 (STE) 和粘弹性 (VE) 是否可以区分正常和异常的放疗后乳房皮肤，并将这些方法与 20 Gy 阈值下的 RTOG 标准进行比较。满足纳入和排除的患者标准在同一天进行了 PA、STE 和 VE。收集的数据包括放射剂量、分子类型、RTOG、Fitzpatrick 皮肤类型、病理学、新辅助化疗状态、TNM 分类、手术程序、原发性乳腺癌部位、BMI 和年龄。使用双样本 t 检验确定 41 名患者的样本。采用T检验、方差分析、秩和检验、卡方检验等统计工具，以及随机森林分析和ROC曲线来评估辐射剂量效应。66名患者的数据显示真皮等参数存在显着差异以及皮下组织氧饱和度、真皮厚度和皮肤弹性（p 值 < 0.05）。然而，氧饱和度的最小值和一些光声测量值没有显着差异。值得注意的是，在 20 Gy 辐射阈值下，观察到氧饱和度、异常真皮厚度以及皮肤 STE 和 VE 的显着变化，证明比 RTOG 分级更准确。该研究证实了 PA 和弹性成像在区分正常与异常乳房方面的有效性组织并评估辐射引起的变化，突出这些成像技术的潜力。版权所有 © 2024。由 Elsevier Inc. 出版。

This study evaluates whether photoacoustic (PA), sound touch elastography (STE), and viscoelasticity (VE) can distinguish between normal and abnormal post-radiotherapy breast skin and compare these methods with RTOG criteria at a 20 Gy threshold.Patients meeting inclusion and exclusion criteria underwent PA, STE, and VE on the same day. Collected data included radiation dose, molecular type, RTOG, Fitzpatrick skin type, pathology, neoadjuvant chemotherapy status, TNM classification, surgical procedures, primary breast cancer location, BMI, and age. A sample of 41 patients was determined using a two-sample t-test. Statistical tools like T-tests, variance analysis, rank sum tests, and chi-square tests, along with random forest analysis and ROC curves, were used to evaluate the radiation dose effects.Data from 66 patients showed significant differences in parameters such as dermis and subcutaneous tissue oxygen saturation, dermal thickness, and skin elasticity (p-values < 0.05). However, minimum values of oxygen saturation and some photoacoustic measures were not significantly different. Notably, at a 20 Gy radiation threshold, significant variations in oxygen saturation, abnormal dermal thickness, and skin STE and VE were observed, proving more accurate than RTOG grading.The study confirms the effectiveness of PA and elastography imaging in differentiating normal from abnormal breast tissue and assessing radiation-induced changes, highlighting the potential of these imaging techniques.Copyright © 2024. Published by Elsevier Inc.