乳腺癌和生殖道恶性肿瘤对青少年和青年（AYA）组15-39岁女性的身心健康，特别是生殖功能的影响显着。本研究旨在分析 1990 年至 2021 年全球各个地区和国家 AYA 女性癌症的负担。流行病学数据来源于 2021 年全球疾病负担 (GBD) 研究。该研究分析了女性癌症（乳腺癌、卵巢癌、子宫和宫颈）来评估不同年龄、年份和地点的疾病负担，涵盖 21 个 GBD 区域、195 个国家和 5 个社会人口指数 (SDI) 区域。 2021 年，AYA 女性癌症新增病例 383 241 例，死亡 81 679 例全球范围内，有 2 975 183 例流行病例和 4 855 780 个伤残调整生命年。 2021年，拉丁美洲中部的年龄标准化发病率（ASIR）和患病率（ASPR）最高，而南撒哈拉以南非洲地区的年龄标准化死亡率（ASMR）和残疾率（ASDR）最高。 SDI 高的国家通常表现出较高的 ASIR 和 ASPR，而 ASMR 和 ASDR 则表现出相反的模式。在过去三十年中，全球 AYA 女性中女性癌症的 ASIR 和 ASPR 有所增加。相比之下，ASMR和ASDR则呈现下降趋势。值得注意的是，乳腺癌成为 AYA 女性中最常见的恶性肿瘤。在过去三十年中，AYA 女性癌症的 ASIR 和 ASPR 持续增加，给这一人群带来了巨大负担。此外，不同地区和国家之间存在明显的差异，与高 SDI 环境中的女性相比，低 SDI 环境中的 AYA 女性的预后较差。因此，加强区域间合作和沟通以优化 AYA 女性癌症的整体预后势在必行。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

The impact of breast carcinoma and genital tract malignancy on the physical and mental health, especially reproductive function, of women aged 15-39 years in the adolescent and young adult (AYA) group is significant. This research aims to analyze the burden of AYA female cancer in various regions and countries globally from 1990 to 2021.Epidemiological data were sourced from the Global Burden of Disease (GBD) study 2021. The study analyzed data on female cancers (breast, ovarian, uterine, and cervical) to assess disease burden across different ages, years, and locations, encompassing 21 GBD regions, 195 countries, and five sociodemographic index (SDI) regions.In 2021, AYA female cancer saw 383 241 new cases and 81 679 deaths globally, with 2 975 183 prevalent cases and 4 855 780 disability-adjusted life years. In 2021, Central Latin America recorded the highest age-standardized incidence (ASIR) and prevalence rates (ASPR), whereas South sub-Saharan Africa had the highest age-standardized mortality (ASMR) and disability rates (ASDR). Nations with high SDI typically exhibited elevated ASIR and ASPR, whereas ASMR and ASDR demonstrated inverse patterns. Over the past three decades, ASIR and ASPR of female cancers among AYA women have increased globally. In contrast, the ASMR and ASDR have demonstrated a declining trend. Notably, breast cancer emerged as the most prevalent malignancy among AYA women.Over the past three decades, the ASIR and ASPR of AYA female cancers have consistently increased, significantly burdening this demographic. Additionally, pronounced disparities are evident across different regions and countries, with AYA women in low SDI environments experiencing poorer prognoses compared to their counterparts in high SDI environments. Consequently, it is imperative to enhance interregional collaboration and communication to optimize the overall prognosis of AYA female cancers.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.